First-pass extracted concept

centrosomal glutamylation

Candidate: concept label1 source documents4 linked claims

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Evidence Snippets

Centrosomes are tubulin-based organelles that undergo glutamylation

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional effectsupports2025Source 1DOI PubMed

Centrosome glutamylation promotes proper mitotic spindle formation and mitosis.

Quoted textsource-backed

Centrosome glutamylation also promotes proper mitotic spindle formation and mitosis.

Claim 2functional effectsupports2025Source 1DOI PubMed

Centrosome structure remains largely unaffected by centrosomal hypoglutamylation.

Quoted textsource-backed

We found that centrosome structure remains largely unaffected by centrosomal hypoglutamylation.

Claim 3functional effectsupports2025Source 1DOI PubMed

Recruitment of the NEDD1/CEP192/γ-tubulin complex by centrosomal glutamylation ensures microtubule nucleation and proper centriolar satellite trafficking.

Quoted textsource-backed

ensuring microtubule nucleation and proper trafficking of centriolar satellites

Claim 4mechanismsupports2025Source 1DOI PubMed

Centrosomal glutamylation physically recruits the NEDD1/CEP192/γ-tubulin complex to centrosomes via electrostatic forces.

Quoted textsource-backed

glutamylation physically recruits, via electrostatic forces, the NEDD1/CEP192/γ-tubulin complex to centrosomes