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ceramide signaling

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In this article, ceramide signaling will be reviewed in light of 'systems interface biology': as an interconnection of sphingolipid metabolism, membrane biophysics and cell signaling.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1biological significancesupports2008Source 1DOIPubMed

Ceramide/sphingomyelin- and ceramide/sphingosine-1-phosphate-interdependent signaling pathways are significant for regulation of cell polarity, apoptosis, and/or proliferation.

Quoted textsource-backed
Ceramide/sphingomyelin and ceramide/sphingosine-1-phosphate-interdependent cell-signaling pathways are significant for the regulation of cell polarity, apoptosis and/or proliferation
Claim 2conceptual frameworksupports2008Source 1DOIPubMed

Ceramide signaling can be framed as an interconnection of sphingolipid metabolism, membrane biophysics, and cell signaling.

Quoted textsource-backed
ceramide signaling will be reviewed in light of 'systems interface biology': as an interconnection of sphingolipid metabolism, membrane biophysics and cell signaling
Claim 3functional rolesupports2008Source 1DOIPubMed

Previous work has mainly focused on ceramide as an apoptosis inducer.

Quoted textsource-backed
Most of the previous work on the sphingolipid ceramide has been devoted to its function as an apoptosis inducer.
Claim 4functional rolesupports2008Source 1DOIPubMed

Recent studies have shown that in stem cells ceramide has additional nonapoptotic functions.

Quoted textsource-backed
Recent studies, however, have shown that in stem cells, ceramide has additional nonapoptotic functions.
Claim 5mechanistic relationshipsupports2008Source 1DOIPubMed

The review focuses on metabolic interconversion of ceramide with sphingomyelin and sphingosine-1-phosphate.

Quoted textsource-backed
The focus will be on the metabolic interconversion of ceramide and sphingomyelin or sphingosine-1-phosphate.
Claim 6translational relevancesupports2008Source 1DOIPubMed

Ceramide/sphingomyelin and ceramide/sphingosine-1-phosphate signaling pathways are presented as novel pharmacologic targets in cancer and stem cells.

Quoted textsource-backed
Ceramide/sphingomyelin and ceramide/sphingosine-1-phosphate-interdependent cell-signaling pathways are significant for the regulation of cell polarity, apoptosis and/or proliferation, and as novel pharmacologic targets in cancer and stem cells.