Back to first-pass browser

First-pass extracted concept

cerebellar nuclei modulation

Candidate: concept label1 source documents5 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Aliases

cerebellar output modulation, CN neuron activity modulation

Extracted Explainers

What the tool is doing

This is the intervention concept tested in the paper: changing cerebellar nuclei firing to alter generalized spike-and-wave discharge occurrence.

Source 1DOIPubMed

Evidence Snippets

We investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN) is effective in controlling absence seizures.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1functional effectsupports2015Source 1DOIPubMed

Manipulating cerebellar nuclei neuron activity modulates generalized spike-and-wave discharge occurrence.

Quoted textsource-backed
manipulating this activity modulates GSWD occurrence
Claim 2intervention effectsupports2015Source 1DOIPubMed

A single short optogenetic stimulation of cerebellar nuclei neuron activity abruptly stopped generalized spike-and-wave discharges, including with unilateral stimulation.

Quoted textsource-backed
A single short-lasting (30-300 milliseconds) optogenetic stimulation of CN neuron activity abruptly stopped GSWDs, even when applied unilaterally.
Claim 3mechanistic associationsupports2015Source 1DOIPubMed

A subset of cerebellar nuclei neurons shows phase-locked oscillatory firing during generalized spike-and-wave discharges.

Quoted textsource-backed
We found that a subset of CN neurons show phase-locked oscillatory firing during GSWDs
Claim 4perturbation effectsupports2015Source 1DOIPubMed

Gabazine-mediated increase in cerebellar nuclei firing frequency and regularity decimated generalized spike-and-wave discharge occurrence.

Quoted textsource-backed
increasing the frequency and regularity of CN neuron firing with the use of GABA-A antagonist gabazine decimated its occurrence
Claim 5perturbation effectsupports2015Source 1DOIPubMed

Local muscimol inhibition of cerebellar nuclei neuron firing increased generalized spike-and-wave discharge occurrence up to 37-fold.

Quoted textsource-backed
Inhibiting CN neuron action potential firing by local application of the γ-aminobutyric acid type A (GABA-A) agonist muscimol increased GSWD occurrence up to 37-fold