Cystic fibrosis transmembrane transduction regulator (CFTR) has been demonstrated to be a mechanically sensitive channel, mediating anionic transmembrane flow.
First-pass extracted concept
CFTR
Candidate: concept label1 source documents4 linked claims
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Aliases
Cystic fibrosis transmembrane transduction regulator
Evidence Snippets
Supporting Sources
Linked Claims
Low-intensity ultrasound activates CFTR-mediated transmembrane chloride flow in CFTR-expressing HEK293T cells.
Quoted textsource-backed
Outward currents in CFTR-expressed HEK293T cells were observed by using whole-cell patch clamp when ultrasound (0.8 MHz, 0.20 MPa) was delivered to these cells.
This study reports ultrasound regulation of an anion channel, whereas previously reported ultrasound-sensitive channels were cation channels.
Quoted textsource-backed
Currently, all channels that have been shown to be sensitive to ultrasound are cation channels... However, there have been no research on ultrasound regulation of anion channels until now.
Forskolin increased the amplitude of ultrasound-evoked currents in CFTR-expressing HEK293T cells.
Quoted textsource-backed
Meanwhile, the amplitude of these currents increased when the CFTR agonist (Forskolin) was applied.
Ultrasound-evoked outward currents in CFTR-expressing HEK293T cells were abolished by GlyH101 or by removing chloride ions from the solution.
Quoted textsource-backed
These currents were abolished when the CFTR inhibitor (GlyH101) was applied to the solution or chloride ions was cleared from the solution.