First-pass extracted concept

cGAS-STING pathway

Candidate: concept label1 source documents4 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

cyclic GMP-AMP synthase and stimulator of interferon genes pathway

Evidence Snippets

The activation of the cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway has become a viable technique to elicit innate immune responses against tumors.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1combination strategysupports2025Source 1DOI PubMed

MOFs are being integrated with multimodal strategies to potentiate anticancer immune responses via the cGAS-STING pathway.

Claim 2limitationsupports2025Source 1DOI PubMed

STING agonists face clinical application challenges related to transport efficiency, degradation, and bioavailability.

Claim 3platform rolesupports2025Source 1DOI PubMed

Metal-organic frameworks are adaptable platforms for cancer immunotherapy that can be used for agonist administration or direct activation of the cGAS-STING pathway.

Claim 4utilitysupports2025Source 1DOI PubMed

Activation of the cGAS-STING pathway is a viable technique to elicit innate immune responses against tumors.