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chaperone-mediated autophagy

Candidate: concept label2 source documents4 linked claims
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Aliases

CMA

Evidence Snippets

The title states that the paper reports a fluorescent reporter to track chaperone-mediated autophagy.
Evidence 1Source 1DOIPubMedprovenance
In this study, we have identified a compensatory upregulation of chaperone-mediated autophagy (CMA) in different cellular and mouse models of HD.
Evidence 2Source 2DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1age dependent limitationsupports2011Source 2DOIPubMed

The efficiency of compensatory CMA in Huntington's disease may decrease with age and contribute to cellular failure and pathological manifestations.

Claim 2compensatory crosstalksupports2011Source 2DOIPubMed

CMA activity increases in response to macroautophagic dysfunction in the early stages of Huntington's disease.

Claim 3pathway regulationsupports2011Source 2DOIPubMed

Chaperone-mediated autophagy is compensatorily upregulated in cellular and mouse models of Huntington's disease.

Claim 4tool purposesupports2011Source 1DOIPubMed

The paper describes a photoconvertible fluorescent reporter for tracking chaperone-mediated autophagy.

Quoted textsource-backed
A photoconvertible fluorescent reporter to track chaperone-mediated autophagy