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chemogenetic locus coeruleus activation

Candidate: concept label1 source documents5 linked claims
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Aliases

LC activation, LC stimulation

Evidence Snippets

chemogenetic activation of the LC
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1correlationsupports2019Source 1DOIPubMed

Functional connectivity changes correlate with transcript levels of alpha-1 and beta-1 adrenergic receptors across the brain.

Quoted textsource-backed
Functional connectivity changes strongly correlate with transcript levels of alpha-1 and beta-1 adrenergic receptors across the brain
Claim 2correlationsupports2019Source 1DOIPubMed

Functional network connectivity correlates with norepinephrine turnover within select brain regions.

Quoted textsource-backed
functional network connectivity correlates with NE turnover within select brain regions
Claim 3functional effectsupports2019Source 1DOIPubMed

LC activation rapidly interrupts ongoing behavior and strongly increases brain-wide connectivity.

Quoted textsource-backed
We show that LC activation rapidly interrupts ongoing behavior and strongly increases brain-wide connectivity
Claim 4method namingsupports2019Source 1DOIPubMed

The paper terms the combination of chemogenetic LC activation and resting-state fMRI "chemo-connectomics."

Quoted textsource-backed
combining chemogenetic activation of the LC with resting-state fMRI, an approach we term "chemo-connectomics."
Claim 5network specific effectsupports2019Source 1DOIPubMed

The strongest connectivity effects after LC activation occur in the salience and amygdala networks.

Quoted textsource-backed
with the most profound effects in the salience and amygdala networks