The abstract identifies chemogenetic methods as one of the approaches associated with discovery of additional striatal GABAergic interneuron subtypes and their synaptic networks.
First-pass extracted concept
chemogenetic methods
Candidate: concept label4 source documents9 linked claims
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chemogenetic
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Chemogenetic methods, which combine the selective expression of designer receptors with designer drugs, have rapidly grown in use in the neurosciences, including in epilepsy.
With the application of new transgenic fluorescent reporter and Cre-driver/reporter lines, plus optogenetic, chemogenetic and viral transduction methods, several additional subtypes of novel striatal GABAergic interneurons have been discovered
Over the past decade, optogenetic and chemogenetic tools have enabled previously impossible levels of functional circuit mapping in neuroscience.
When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases and with chronic stimulation mice lose body weight.
Supporting Sources
Linked Claims
Chemogenetic methods combining designer receptors with designer drugs have rapidly grown in use in neuroscience, including epilepsy.
Current epilepsy pharmacotherapies modulate neuronal excitability, but disrupting patterned neuronal excitation that is essential to normal function leads to side effects.
The efficacy of current pharmacotherapy for epilepsies remains incomplete despite decades of drug development.
Striatal GABAergic interneurons participate in highly selective afferent inputs and synaptic connections among interneuron subtypes and spiny neurons that form functional networks and ensembles of spiny neurons.
New transgenic fluorescent reporter and Cre-driver/reporter lines together with optogenetic, chemogenetic, and viral transduction methods enabled discovery of additional subtypes of striatal GABAergic interneurons and the synaptic networks in which they are embedded.
The hypothesis that striatal GABAergic interneurons control spiny neuron firing principally by simple feedforward or feedback inhibition is incomplete.
Understanding network architecture at the level of local microcircuits and distributed macrocircuits may provide new therapeutic avenues for the treatment of epilepsy.
Quoted textsource-backed
Understanding the network architecture at the level of both local microcircuits and distributed macrocircuits may provide new therapeutic avenues for the treatment of epilepsy.
Optogenetic and chemogenetic tools have enabled previously impossible levels of functional circuit mapping in neuroscience.
Quoted textsource-backed
Over the past decade, optogenetic and chemogenetic tools have enabled previously impossible levels of functional circuit mapping in neuroscience.
Activation of CCK-expressing and DBH-expressing NTS neurons using optogenetic or chemogenetic methods decreases food intake.
Quoted textsource-backed
When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases