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chloride-conducting channelrhodopsins

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Aliases

light-activated chloride channels

Evidence Snippets

The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1engineering resultsupports2015Source 1DOIPubMed

First-generation engineered chloride-conducting channelrhodopsins became chloride selective and reversed near -65 mV, but had small photocurrents and were not tested for optogenetic inhibition of behavior.

Quoted textsource-backed
Engineered channels indeed became chloride selective, reversing near -65 mV and enabling a new kind of optogenetic inhibition; however, these first-generation chloride-conducting channels displayed small photocurrents and were not tested for optogenetic inhibition of behavior.
Claim 2mechanism and designsupports2015Source 1DOIPubMed

Structure-guided design of chloride-conducting channelrhodopsins illuminated mechanisms underlying channelrhodopsin ion selectivity.

Quoted textsource-backed
The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity
Claim 3mechanistic insightsupports2015Source 1DOIPubMed

Inhibition by light-gated chloride channels is mediated mainly by shunting effects and is more efficient for optogenetic control than hyperpolarization induced by light-activated chloride pumps.

Quoted textsource-backed
We further show that inhibition by light-gated chloride channels is mediated mainly by shunting effects, which exert optogenetic control much more efficiently than the hyperpolarization induced by light-activated chloride pumps.