First-pass extracted concept

cholinergic anti-inflammatory pathway

Candidate: concept label2 source documents4 linked claims

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Aliases

CAP

Evidence Snippets

The review scope explicitly emphasizes cholinergic anti-inflammatory signaling in AKI.

Evidence 1Source 1DOI PubMedprovenance

The supplied web research summary states that the review centers on the inflammatory reflex/cholinergic anti-inflammatory pathway in kidney disease.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2018Seminars in NephrologyDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2review2017Nature Reviews NephrologyDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1mechanistic review summarysupports2018Source 1DOI PubMed

The review context links vagus nerve stimulation and pulsed ultrasound to activation of the cholinergic anti-inflammatory pathway in the setting of acute kidney injury.

Claim 2review scope summarysupports2018Source 1DOI PubMed

This review synthesizes evidence that the neuroimmune axis is relevant to acute kidney injury and discusses cholinergic anti-inflammatory signaling, vagus nerve stimulation, pulsed ultrasound, renal innervation, and optogenetic circuit analysis as key components of that topic.

Claim 3intervention summarysupports2017Source 2DOI PubMed

The review discusses pulsed ultrasound as a nonpharmacologic intervention that can activate spleen-associated cholinergic anti-inflammatory signaling relevant to kidney injury.

Claim 4review scopesupports2017Source 2DOI PubMed

This review synthesizes neural reflex circuit mechanisms that regulate immunity as potential treatment strategies for kidney disease.