Back to first-pass browser

First-pass extracted concept

chromosome dynamics

Candidate: concept label1 source documents5 linked claims
Jump to explainersJump to evidenceJump to sourcesJump to claims
Live refresh every 5sNext refresh in 5s

Extracted Explainers

What the tool is doing

Chromosome dynamics are measured in single live zebrafish cells and increase during sleep in individual neurons. The paper presents this readout as a potential marker of single sleeping cells.

Source 1DOIPubMed

Resources required

The abstract supports a need for time-lapse imaging of chromosomal markers in single cells of live zebrafish.

Source 1DOIPubMed

What problem it solves

It offers a candidate cellular-level marker for sleep and a mechanistic link between sleep and reduction of neuronal DNA damage.

Source 1DOIPubMed

What it does not solve

The abstract does not show that chromosome dynamics are a conserved marker across phylogeny, and it reports no increase in two other tested cell types.

Source 1DOIPubMed

Alternatives

The abstract contrasts chromosome dynamics with the lack of a conserved molecular marker to define sleep across phylogeny.

Source 1DOIPubMed

Evidence Snippets

Time-lapse imaging of chromosomal markers in single cells of live zebrafish revealed that sleep increases chromosome dynamics in individual neurons but not in two other cell types.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1causal mechanismsupports2019Source 1DOIPubMed

Sleep increases chromosome dynamics, and these dynamics are necessary to reduce DNA double-strand breaks.

Quoted textsource-backed
In turn, sleep increases chromosome dynamics, which are necessary to reduce the amount of DSBs.
Claim 2functional hypothesissupports2019Source 1DOIPubMed

The restorative function of sleep is proposed to be nuclear maintenance.

Quoted textsource-backed
and propose that the restorative function of sleep is nuclear maintenance.
Claim 3marker proposalsupports2019Source 1DOIPubMed

Chromosome dynamics are proposed as a potential marker to define single sleeping cells.

Quoted textsource-backed
These results establish chromosome dynamics as a potential marker to define single sleeping cells
Claim 4state associationsupports2019Source 1DOIPubMed

During wakefulness, chromosome dynamics are low and DNA double-strand breaks accumulate.

Quoted textsource-backed
Manipulation of sleep, chromosome dynamics, neuronal activity, and DNA double-strand breaks (DSBs) showed that chromosome dynamics are low and the number of DSBs accumulates during wakefulness.
Claim 5state associationsupports2019Source 1DOIPubMed

In live zebrafish, sleep increases chromosome dynamics in individual neurons but not in two other cell types.

Quoted textsource-backed
Time-lapse imaging of chromosomal markers in single cells of live zebrafish revealed that sleep increases chromosome dynamics in individual neurons but not in two other cell types.