First-pass extracted concept

chronic social defeat stress

Candidate: concept label3 source documents8 linked claims

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Aliases

CSDS

Extracted Explainers

What the tool is doing

CSDS is described as a frequently used mouse model for depression. It is included among the chronic stress paradigms used to study dendritic spine remodeling.

Source 2DOI PubMed

CSDS is the behavioral paradigm used to define susceptibility and resilience in mice in this study.

Source 3DOI PubMed

Resources required

The abstract supports that the work is done in mice under a chronic social defeat stress paradigm, but does not provide procedural details.

Source 3DOI PubMed

What problem it solves

It provides a commonly used stress-based depression model in rodents.

Source 2DOI PubMed

It provides the disease-relevant context in which circuit manipulations are linked to depression-related susceptibility phenotypes.

Source 3DOI PubMed

What it does not solve

The abstract states that it is limited to the study of male mice.

Source 2DOI PubMed

The abstract does not establish that CSDS captures all aspects of human depression or specify how broadly the findings generalize.

Source 3DOI PubMed

Alternatives

The abstract lists CRS and CUMS as alternative chronic stress models.

Source 2DOI PubMed

Evidence Snippets

In rodents, the chronic social defeat stress (CSDS) model has been used to understand the neurobiology underlying stress susceptibility versus resilience following social trauma

Evidence 1Source 1DOI PubMedprovenance

CSDS is one of the most frequently used models for depression, but it is limited to the study of male mice.

Evidence 2Source 2DOI PubMedprovenance

glutamatergic vHIP afferents to NAc regulate susceptibility to chronic social defeat stress (CSDS)

Evidence 3Source 3DOI PubMedprovenance

Supporting Sources

Source 1primary paper2022NatureDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 2review2016Neural PlasticityDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 3primary paper2015Nature CommunicationsDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1behavioral phenotypesupports2022Source 1DOI PubMed

Following chronic social defeat stress, a subset of male and female mice classified as susceptible avoid social interaction with non-aggressive same-sex juvenile C57BL/6J mice and fail to develop context-dependent social reward from those encounters.

Claim 2limitationsupports2016Source 2DOI PubMed

CSDS is one of the most frequently used models for depression but is limited to the study of male mice.

Claim 3model usagesupports2016Source 2DOI PubMed

CRS, CUMS, and CSDS have been used to recapitulate depression-like behaviors in rodents and to study underlying mechanisms.

Claim 4causal perturbation effectsupports2015Source 3DOI PubMed

Acute enhancement of ventral hippocampus to nucleus accumbens input is pro-susceptible.

Claim 5causal perturbation effectsupports2015Source 3DOI PubMed

Attenuation of ventral hippocampus to nucleus accumbens transmission by optogenetic induction of long-term depression is pro-resilient.

Claim 6mechanistic rolesupports2015Source 3DOI PubMed

Glutamatergic ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to chronic social defeat stress.

Claim 7specificity comparisonsupports2015Source 3DOI PubMed

The pro-susceptibility effect is specific to ventral hippocampal afferents to the nucleus accumbens because optogenetic stimulation of medial prefrontal cortex or amygdala afferents to the nucleus accumbens is pro-resilient.

Claim 8state associationsupports2015Source 3DOI PubMed

Mice resilient to chronic social defeat stress show reduced activity in the ventral hippocampus.