This label refers to approaches that analyze how multiple brain regions interact to mediate hormone effects on cognition. In this paper, it is presented as a framework for studying estrogenic regulation of episodic memory.
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circuit-based approaches
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This review focuses on studies that have used these circuit-based approaches to gain a more detailed, more comprehensive, and more integrated view on how the PFC governs anxiety and fear
Here, we use estrogenic regulation of episodic memory as an example of how circuit-based approaches may be incorporated into future studies of hormones and cognition.
This Review focuses on studies that have used circuit-based approaches to gain a more detailed, and also more comprehensive and integrated, view on how the brain governs fear and anxiety and how it orchestrates adaptive defensive behaviours.
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Optogenetic and chemogenetic circuit-based approaches allow direct examination of hypotheses drawn from existing psychological concepts.
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allowing direct examination of hypotheses drawn from existing psychological concepts
Rodent models are presented as promising systems for dissecting well-conserved anxiety and fear circuits.
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rodent models hold great promise in dissecting well-conserved circuits
The review synthesizes evidence that newly developed genetic and viral tools together with optogenetic and chemogenetic techniques have enabled more detailed circuit-level analysis of anxiety and fear.
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Newly developed genetic and viral tools and optogenetic and chemogenetic techniques have revealed the intricacies of neural circuits underlying anxiety and fear
Episodic memory formation involves coordinated activity in multiple brain regions.
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Cognitive behaviors, such as episodic memory formation, are complex processes involving coordinated activity in multiple brain regions.
Research on hormonal regulation of cognition often focuses on one brain region at a time or provides only a single snapshot of systemic treatment effects across regions without testing how those regions interact.
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However, much of the research on hormonal regulation of cognition focuses on manipulation of one region at a time or provides a single snapshot of how a systemic treatment affects multiple brain regions without investigating how these regions might interact to mediate hormone effects.
Circuit-based approaches may be incorporated into future studies of hormones and cognition using estrogenic regulation of episodic memory as an example.
Quoted textsource-backed
Here, we use estrogenic regulation of episodic memory as an example of how circuit-based approaches may be incorporated into future studies of hormones and cognition.
Studies using these circuit-dissection tools and techniques have provided mechanistic insights into the organization of circuitry underlying internal defensive states.
The review focuses on circuit-based studies that provide a more detailed, comprehensive, and integrated view of how the brain governs fear, anxiety, and adaptive defensive behaviours.