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First-pass extracted concept

circular plasmid donors

Candidate: concept label1 source documents3 linked claims
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Aliases

plasmid donors

Evidence Snippets

In cells receiving circular plasmid donors
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1design principlesupports2026Source 1DOIPubMed

Donor DNA configuration critically influences DNA damage response signaling during targeted insertion.

Quoted textsource-backed
These findings highlight the critical influence of donor DNA configuration on DNA damage response signaling
Claim 2donor dependent effectsupports2026Source 1DOIPubMed

ATM inhibition with AZD1390 markedly reduced knock-in and EJ-TI efficiencies when circular plasmid donors were used.

Quoted textsource-backed
In cells receiving circular plasmid donors, ATM inhibition with AZD1390 markedly reduced the knock-in and EJ-TI efficiencies
Claim 3mechanistic requirementsupports2026Source 1DOIPubMed

ATR activity is essential for knock-in regardless of whether plasmid or AAV donor vectors are used.

Quoted textsource-backed
ATR activity is essential for knock-in regardless of the donor type