circRNAs are described as a subtype of RNA molecules with a closed circular structure and distinctive stability and tissue specificity.
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circular RNAs
Candidate: concept label3 source documents8 linked claims
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circRNAs
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Evidence Snippets
This review synthesizes emerging insights into the diverse roles of circular RNAs (circRNAs) and other circular nucleic acids in viral infection and immunity.
Circular RNAs (circRNAs), a subtype of RNA molecules, possess distinctive characteristics, including their closed circular structure, stability, tissue specificity and long half-life compared to their linear counterparts.
Circular RNAs: Key Regulators of Tumor Metabolic Reprogramming and Clinical Translation
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Linked Claims
circRNAs are associated with development or progression of diseases including cancer, cardiometabolic disorders, and neurodegenerative disorders, supporting diagnostic and therapeutic potential.
Quoted textsource-backed
Notably circRNAs have been associated with the development or progression of diseases (e.g., cancer, cardiometabolic and neurodegenerative disorders), highlighting diagnostic and therapeutic potential.
circRNAs regulate cellular processes including gene expression, transcription, cap-independent translation, microRNA binding, and protein interactions.
Quoted textsource-backed
Insight into their diverse functions revealed their roles, including regulating various cellular processes such as gene expression, transcription, translation into proteins (e.g., cap-independent translation), binding to microRNAs (miRNAs), and interacting with proteins.
CircRNAs can also be exploited by viruses as modulators of immune evasion.
Quoted textsource-backed
These molecules display a striking duality-capable of activating antiviral defenses through pattern recognition receptors such as RIG-I and PKR, yet also exploited by viruses as modulators of immune evasion.
Host-derived circRNAs have a complex interplay with innate immunity and can activate antiviral defenses through RIG-I and PKR.
Quoted textsource-backed
We first discuss the biogenesis and functions of host-derived circRNAs, emphasizing their complex interplay with innate immunity. These molecules display a striking duality-capable of activating antiviral defenses through pattern recognition receptors such as RIG-I and PKR
Advances in RNA-seq and bioinformatics revealed the existence of circRNAs and began to clarify their functions.
Quoted textsource-backed
Initially presumed to be non-functional byproducts of splicing, advances in RNA-seq and bioinformatics have revealed the existence of these RNAs and begun to clarify their functions.
circRNAs have a closed circular structure, stability, tissue specificity, and longer half-life than linear RNA counterparts.
Quoted textsource-backed
Circular RNAs (circRNAs), a subtype of RNA molecules, possess distinctive characteristics, including their closed circular structure, stability, tissue specificity and long half-life compared to their linear counterparts.
Circular RNAs are key regulators of tumor metabolic reprogramming.
Circular RNAs have relevance to clinical translation in the context of tumor metabolic reprogramming.