claustrocortical (ClaC) projection neurons

Activation of corticoclaustral afferents generates monosynaptic excitatory responses and disynaptic inhibitory responses in claustrocortical neurons.

Responses to cortical input are comparatively stronger in parvalbumin-positive interneurons than in claustrocortical neurons.

Claustrocortical neurons and parvalbumin-positive interneurons form frequent synaptic connections.

Unitary synaptic connections among claustrocortical projection neurons are rare.

Recurrent excitatory circuits within the claustrum alone are unlikely to integrate across multiple sensory modalities.

The reported claustral cellular organization is consistent with circuits sensitive to correlated inputs and with roles in sensory novelty detection or amplification of correlated cortical inputs.

Corticoclaustral afferents form monosynaptic connections onto both claustrocortical neurons and parvalbumin-positive interneurons.