coagulation cascade-mediated endothelial RNA delivery

This concept describes endothelial RNA delivery in vivo as being mediated by activation of the coagulation cascade on nanoparticles. The abstract frames it as the mechanism underlying selective endothelial delivery for certain cationic lipid or polymer formulations.

The abstract indicates a nanoparticle RNA delivery system and coagulating or procoagulant proteins/components are required. Exact proteins, cargos, and formulations are not specified in the provided evidence.

It helps explain how some nanoparticles achieve endothelial delivery rather than only passive distribution. It also suggests a route to retarget delivery by manipulating coagulation-related surface interactions.

The abstract does not show that this mechanism avoids all coagulation-related safety risks beyond lack of histological clot evidence. It also does not specify how broadly the mechanism generalizes across nanoparticle classes.

The abstract contrasts this mechanism with nanoparticles previously reported to transfect the liver, implying conventional liver-directed behavior as an alternative baseline. No other mechanistic alternatives are explicitly named in the source text.