The development of coelenterazine-type bioluminescence-induced photosensory domain-based probes has been applied in the imaging, sensing, and control of cellular activities, signaling pathways, and synthetic genetic circuits in vitro and in vivo.
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coelenterazine-type bioluminescence-induced photosensory domain-based probes
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Bioluminescence-based probes have long been used to quantify and visualize biological processes in vitro and in vivo.
Coelenterazine-type bioluminescence-induced photosensory domain-based probes have been applied to imaging, sensing, and control of cellular activities, signaling pathways, and synthetic genetic circuits in vitro and in vivo.
In bioluminescence-driven optogenetic systems, bioluminescence from coelenterazine-type luciferin-luciferase reactions activates light-sensitive proteins that induce downstream events.
This strategy can shed light on disease mechanisms and promote interrelated therapy development.