First-pass extracted concept

compartmentalized cAMP signaling in the primary cilium

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Recent studies now suggest it is a specific pool of cAMP generated in the cilium that propels cyst formation in ADPKD, supporting the notion that this antenna-like organelle is a compartment within which cAMP signaling occurs independently from cAMP signaling in the bulk cytosol.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2023Frontiers in PhysiologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review summarysupports2023Source 1DOI PubMed

Ciliary membrane localization of GPCRs determines their downstream function.

Claim 2review summarysupports2023Source 1DOI PubMed

Optogenetic tools have helped establish that cAMP generated in the primary cilium can drive cystogenesis.

Claim 3review summarysupports2023Source 1DOI PubMed

Recent studies suggest that a specific pool of cAMP generated in the primary cilium propels cyst formation in ADPKD, supporting the primary cilium as an independent cAMP signaling compartment.