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First-pass extracted concept

Complement C4A (C4A)

Candidate: concept label1 source documents3 linked claims
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Aliases

C4A

Evidence Snippets

with two proteins remaining significant after multiple testing correction: complement C4A (C4A) and afamin (AFM).
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1multiple testing significancesupports2025Source 1DOIPubMed

AFM and C4A were the only two EV proteins that remained significant after multiple testing correction.

Quoted textsource-backed
with two proteins remaining significant after multiple testing correction: complement C4A (C4A) and afamin (AFM)
Claim 2severity associationsupports2025Source 1DOIPubMed

In severe hepatic steatosis, EV subgroup analysis showed increased COL18A1, AFM, PRG4, and INHBE and decreased C4A and APOA1.

Quoted textsource-backed
In participants with severe hepatic steatosis (n = 43), subgroup analysis showed increased COL18A1, AFM, PRG4, and INHBE and decreased C4A and APOA1.
Claim 3subgroup associationsupports2025Source 1DOIPubMed

In Black women, AFM, C4A, and APOA1 were significantly elevated in the EV proteome subgroup analysis.

Quoted textsource-backed
In Black women (n = 172), AFM, C4A, and APOA1 were significantly elevated