First-pass extracted concept

connectivity-based circuit targeting

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

The second uses the spatial connectivity of a circuit to achieve specificity: one genetic element is introduced at the origin of a circuit and the other at its termination. When the two genetic elements combine within a neuron, they can alter its function.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2016NeurotherapeuticsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1approach combinationsupports2016Source 1DOI PubMed

Genetic-identity-based and connectivity-based targeting approaches can be combined to manipulate neurons with a specific genetic identity within a defined circuit.

Claim 2comparative assessmentsupports2016Source 1DOI PubMed

The review considers advantages and disadvantages of the two general circuit-targeting approaches with regard to specificity and efficacy of manipulations.

Claim 3review scope summarysupports2016Source 1DOI PubMed

The review describes two general approaches for achieving neural circuit specificity: targeting by genetic identity and targeting by spatial connectivity.