First-pass extracted concept

COP9 signalosome

Candidate: concept label1 source documents3 linked claims

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Aliases

CSN

Evidence Snippets

COP9 signalosome (CSN) and Den1/A deneddylases physically interact and promote multicellular development in fungi.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019BiomoleculesDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1gene regulationsupports2019Source 1DOI PubMed

An intact COP9 signalosome represses uspA gene expression.

Claim 2mechanistic modelsupports2019Source 1DOI PubMed

Interplay between COP9 signalosome deneddylase, UspA deubiquitinase, and SCF-Fbx23 ensures accurate VeA levels that support fungal development and appropriate secondary metabolism.

Claim 3physical interactionsupports2019Source 1DOI PubMed

UspA interacts with six COP9 signalosome subunits in Aspergillus nidulans.