First-pass extracted concept

cortical layer 1 (L1)

Candidate: concept label1 source documents4 linked claims

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Aliases

L1, layer 1

Evidence Snippets

We will focus on L1, its afferents, intrinsic neurons and its influence on responses of pyramidal neurons in layers 2/3 and 5.

Evidence 1Source 1DOIprovenance

Supporting Sources

Source 1review2015Frontiers in Neural CircuitsDOI

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1cellular propertysupports2015Source 1DOI

Layer 1 cells are described in the abstract as GAD67-positive and therefore inhibitory.

Claim 2future capabilitysupports2015Source 1DOI

Genetic tools may enable detection of normal activity from individual sources of layer 1 input.

Claim 3mechanistic hypothesissupports2015Source 1DOI

Layer 1 inhibitory cells could reverse the sign of thalamic glutamatergic input for the cortex.

Claim 4review summarysupports2015Source 1DOI

Recent advances including recognition of layer 1 neurons, active conduction along apical dendrites, and optogenetic methods have made cortical layer 1 more experimentally tractable.