First-pass extracted concept

cortico-basal ganglia circuits

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Here we discuss the role of the basal ganglia and connected prefrontal regions in the etiology and treatment of obsessive-compulsive disorder, anxiety, and depression, emphasizing mechanistic work in rodent behavioral models to dissect causal cortico-basal ganglia circuits underlying discrete behavioral symptom domains relevant to these complex disorders.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2015Annual Review of PhysiologyDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2015Source 1DOI PubMed

Many psychiatric disorders are associated with abnormal activity in the prefrontal cortex and basal ganglia.

Claim 2evidence emphasissupports2015Source 1DOI PubMed

The review emphasizes mechanistic work in rodent behavioral models to dissect causal cortico-basal ganglia circuits underlying discrete behavioral symptom domains relevant to psychiatric disorders.

Claim 3review scope statementsupports2015Source 1DOI PubMed

The review synthesizes evidence on the role of basal ganglia and connected prefrontal regions in the etiology and treatment of obsessive-compulsive disorder, anxiety, and depression.