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cPLA2-GADD34 pathway

Candidate: concept label1 source documents6 linked claims
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Aliases

cPLA2, GADD34, Ppp1r15, Ppp1r15a

Evidence Snippets

loss of β2-integrin adhesion leads to nuclear deformation and activation of a cPLA2-GADD34 pathway in BMDCs, which at least partly controls their activated phenotype.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1gene expression changesupports2026Source 1DOIPubMed

GADD34 is upregulated in datasets associated with loss of β2-integrin adhesion and nuclear deformation.

Quoted textsource-backed
Growth arrest and DNA damage-inducible protein (GADD34; Ppp1r15) of the unfolded protein responses was also upregulated in both datasets.
Claim 2mechanistic modelsupports2026Source 1DOIPubMed

Loss of β2-integrin adhesion leads to nuclear deformation and activation of a cPLA2-GADD34 pathway that partly controls the activated phenotype of bone marrow-derived dendritic cells.

Quoted textsource-backed
Together, our results show that loss of β2-integrin adhesion leads to nuclear deformation and activation of a cPLA2-GADD34 pathway in BMDCs, which at least partly controls their activated phenotype.
Claim 3mechanistic regulationsupports2026Source 1DOIPubMed

cPLA2 controls interleukin-12 production and CD86 expression in β2-integrin adhesion-deficient bone marrow-derived dendritic cells.

Quoted textsource-backed
Utilizing a cytosolic phospholipase A2 (cPLA2) inhibitor, we show that the nuclear shape sensor cPLA2 controls interleukin-12 production and CD86 expression of β2-integrin adhesion-deficient BMDCs.
Claim 4pathway activationsupports2026Source 1DOIPubMed

The GADD34 pathway is activated in adhesion-deficient bone marrow-derived dendritic cells and is associated with reduced EIF2α phosphorylation.

Quoted textsource-backed
We further show that the GADD34 pathway is activated in adhesion-deficient BMDCs, as eukaryotic translation initiation factor 2A (EIF2α) phosphorylation is reduced in these cells
Claim 5perturbation effectsupports2026Source 1DOIPubMed

cPLA2 inhibition rescues EIF2α phosphorylation in adhesion-deficient bone marrow-derived dendritic cells.

Quoted textsource-backed
whilst cPLA2 inhibition rescues EIF2α phosphorylation
Claim 6perturbation effectsupports2026Source 1DOIPubMed

GADD34 inhibition decreases interleukin-12 production and CD86 expression in β2-integrin-deficient bone marrow-derived dendritic cells, whereas PERK inhibition has no effect.

Quoted textsource-backed
GADD34 inhibition led to decreased interleukin-12 production and CD86 expression in β2-integrin-deficient BMDCs, whilst inhibition of protein kinase R-like endoplasmic reticulum kinase (the canonical EIF2α kinase) had no effect.