First-pass extracted concept

CRISPR-guided systems with associated integrase machinery

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Through a historical analysis, we observe ... a recent rise in the use of CRISPR-guided systems that consist of associated integrase machinery.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1capability statementsupports2025Source 1DOI PubMed

Precise genome DNA payload insertion enables comprehensive engineering of cellular phenotypes and creation of new biotechnologies.

Claim 2design goalsupports2025Source 1DOI PubMed

The review focuses on bacterial genome integration systems that are precise, self-contained, portable, and place minimal requirements on the host cell.

Claim 3trend statementsupports2025Source 1DOI PubMed

Historical analysis indicates long-term use of recombineering technologies, a recent rise of CRISPR-guided systems with associated integrase machinery, and growing efforts to modify non-model organisms.