First-pass extracted concept

critical periods of vulnerability in nervous system development

Candidate: concept label1 source documents4 linked claims
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Aliases

vulnerable periods, windows of vulnerability

Extracted Explainers

What the tool is doing

This concept frames neurodevelopment as containing time-limited windows in which environmental insults can have disproportionate effects. The review ties these windows to the emergence of proliferation, migration, differentiation, synaptogenesis, myelination, and apoptosis.

Source 1DOIPubMed

What problem it solves

It helps explain why the same insult can have different consequences depending on developmental timing and brain region.

Source 1DOIPubMed

What it does not solve

The abstract does not provide a precise staging system or a single experimental method for identifying these windows.

Source 1DOIPubMed

Alternatives

The review contrasts broad human and animal evidence rather than naming an alternative conceptual framework.

Source 1DOIPubMed

Evidence Snippets

Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1review summarysupports2000Source 1DOIPubMed

Neural development extends from the embryonic period through adolescence.

Quoted textsource-backed
Evidence from numerous sources demonstrates that neural development extends from the embryonic period through adolescence.
Claim 2review summarysupports2000Source 1DOIPubMed

Ontogeny of specific behaviors can be used to infer maturation of specific brain structures or neural circuits in rodents, primates, and humans.

Quoted textsource-backed
the ontogeny of specific behaviors can be used to draw inferences regarding the maturation of specific brain structures or neural circuits in rodents and primates, including humans
Claim 3review summarysupports2000Source 1DOIPubMed

Periods of nervous system development are especially vulnerable to environmental insults because susceptibility depends on the temporal and regional emergence of critical developmental processes.

Quoted textsource-backed
Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes
Claim 4review summarysupports2000Source 1DOIPubMed

The sequence of major neurodevelopmental events is broadly comparable among species, although the time scales differ considerably.

Quoted textsource-backed
In general, the sequence of events is comparable among species, although the time scales are considerably different.