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CST7+ macrophages/monocytes

Candidate: concept label1 source documents3 linked claims
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Aliases

CST7 (cystatin F)-expressing macrophages/monocytes

Extracted Explainers

What the tool is doing

This label denotes a melanoma myeloid cell population defined by CST7 expression in single-cell analysis. The paper associates this population with an M1-like antitumor phenotype and immunotherapy response.

Source 1DOIPubMed

Resources required

Its identification requires melanoma transcriptomic datasets, especially single-cell RNA-seq data with cell-type annotation and responder/non-responder comparison.

Source 1DOIPubMed

What problem it solves

It helps distinguish responder-associated immune microenvironment states in melanoma.

Source 1DOIPubMed

What it does not solve

The abstract does not show that this population is itself a therapeutic intervention or that CST7 causally drives response.

Source 1DOIPubMed

Alternatives

The source frames this population against broader immune-related hallmarks, prognostic core genes, and cytotoxic T-cell subsets rather than naming a direct substitute biomarker.

Source 1DOIPubMed

Evidence Snippets

The single-cell analysis revealed that CST7 (cystatin F)-expressing macrophages/monocytes were enriched in an M1 macrophage signature, indicative of an antitumor phenotype.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1associationsupports2025Source 1DOIPubMed

CST7+ macrophages/monocytes are more frequent in melanoma immunotherapy responders than in non-responders.

Quoted textsource-backed
These immune cells were significantly more frequent in immunotherapy responders than in non-responders.
Claim 2associationsupports2025Source 1DOIPubMed

CST7+ macrophages/monocytes in melanoma are enriched in an M1 macrophage signature indicative of an antitumor phenotype.

Quoted textsource-backed
The single-cell analysis revealed that CST7 (cystatin F)-expressing macrophages/monocytes were enriched in an M1 macrophage signature, indicative of an antitumor phenotype.
Claim 3mechanistic associationsupports2025Source 1DOIPubMed

A signaling interaction between CST7+ macrophages/monocytes and a cytotoxic T-cell subset via the ICOSL-ICOS axis is more prominent in therapy responders.

Quoted textsource-backed
Further investigation identified a signaling interaction between CST7+ macrophages/monocytes and a cytotoxic T-cell subset via the ICOSL (inducible T-cell costimulator ligand)-ICOS (inducible T-cell costimulator) axis, which was more prominent in therapy responders.