First-pass extracted concept

curcumin analogues

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

The implications of curcumin's (photo)chemical instability are addressed in light of pharmaceutical curcumin preparations, the use of curcumin analogues, and implementation of nanoparticulate drug delivery systems.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2013Pharmacological ReviewsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1bioavailability limitationsupports2013Source 1DOI PubMed

Curcumin has poor bioavailability, with review emphasis on phase I and II metabolism, intestinal first-pass effects, liver second-pass effects, excretion, and systemic clearance of metabolites.

Claim 2molecular target summarysupports2013Source 1DOI PubMed

The review summarizes direct molecular targets of curcumin including the ErbB family of receptors, protein kinase C, enzymes involved in prostaglandin synthesis, vitamin D receptor, and DNA.

Claim 3stability limitationsupports2013Source 1DOI PubMed

Curcumin is susceptible to photochemical and chemical modification and degradation, including alkaline hydrolysis.