This review examines further evidence, both from nonvascular and vascular smooth muscle, for cross talk between the cyclic nucleotides, cAMP and cGMP via their respective protein kinases, and the Ca2+-dependent- and Ca2+-independent-signaling pathways involved in agonist-induced contraction.
First-pass extracted concept
cyclic nucleotide cross talk in smooth muscle
Candidate: concept label1 source documents4 linked claims
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The precise biochemical mechanisms by which cyclic nucleotides inhibit Ca2+ mobilization and thereby smooth muscle contraction remain unresolved.
The review concludes that better methodology and more novel interdisciplinary approaches are needed to elucidate mechanisms of cAMP- and cGMP-mediated inhibition of smooth muscle contraction.
The review summarizes evidence that cAMP and cGMP signaling cross talks with both Ca2+-dependent and Ca2+-independent pathways involved in agonist-induced smooth muscle contraction.
The review states that several targets for cyclic nucleotide inhibition and consequent smooth muscle relaxation include receptors, G proteins, phospholipase C-beta1-4 isoforms, IP3 receptor, Ca2+ mobilization, MLCK, MAP kinase, Rho-kinase, and myosin phosphatase.