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cyclin-dependent kinase 5 knockdown in prelimbic cortex excitatory neurons

Candidate: concept label1 source documents3 linked claims
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Aliases

Cdk5 knockdown, knocking down cyclin-dependent kinase 5

Extracted Explainers

What the tool is doing

This perturbation reduces Cdk5 to test whether it contributes to deactivation of contralateral PL excitatory neurons in chronic pain. The abstract reports rescue of excitability-related and behavioral phenotypes.

Source 1DOIPubMed

Resources required

The abstract supports that a Cdk5 knockdown intervention was used, but it does not identify the construct, vector, promoter, or delivery route.

Source 1DOIPubMed

What problem it solves

It targets a candidate molecular driver of reduced PL excitability associated with pain sensation and anxiety-like behaviors.

Source 1DOIPubMed

What it does not solve

The abstract does not identify the downstream ion channels or synaptic mechanisms through which Cdk5 acts.

Source 1DOIPubMed

Alternatives

The abstract contrasts this molecular intervention with lesion and optogenetic activation or inhibition of PL excitatory neurons.

Source 1DOIPubMed

Evidence Snippets

knocking down cyclin-dependent kinase 5 reverses this deactivation and alleviates behavioural impairments
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1functional rolesupports2015Source 1DOIPubMed

Excitatory neurons in the prelimbic cortex regulate pain sensation and anxiety-like behaviors.

Quoted textsource-backed
Here we demonstrate a role for excitatory neurons in the prelimbic cortex (PL), a sub-region of mPFC, in the regulation of pain sensation and anxiety-like behaviours.
Claim 2mechanistic changesupports2015Source 1DOIPubMed

The intrinsic excitability of contralateral prelimbic cortex excitatory neurons is decreased in chronic pain rats.

Quoted textsource-backed
The intrinsic excitability of contralateral PL excitatory neurons is decreased in chronic pain rats
Claim 3mechanistic rescuesupports2015Source 1DOIPubMed

Knocking down cyclin-dependent kinase 5 reverses deactivation of contralateral prelimbic cortex excitatory neurons and alleviates behavioral impairments.

Quoted textsource-backed
knocking down cyclin-dependent kinase 5 reverses this deactivation and alleviates behavioural impairments