Both, nitric oxide synthase (NOS) and cyclooxygenase (COX) systems, consist of constitutive forms (NOS1, NOS3 and COX-1), which are mostly involved in housekeeping tasks, and inducible forms (NOS2 and COX-2), which shape the cellular response to stress and variety of bioactive agents.
First-pass extracted concept
cyclooxygenase pathway
Candidate: concept label1 source documents6 linked claims
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Aliases
COX pathway, COX system
Evidence Snippets
Supporting Sources
Linked Claims
Constitutive NOS1, NOS3, and COX-1 are mostly involved in housekeeping tasks, whereas inducible NOS2 and COX-2 shape cellular responses to stress and bioactive agents.
The interplay between NOS and COX pathways occurs at at least three levels: regulation of inducible-form expression, reciprocal post-translational modulation, and intracellular signaling crosstalk.
Nitric oxide can modulate prostaglandin synthesis through direct S-nitrosylation of COX.
Peroxynitrite, formed from superoxide reaction with nitric oxide, can inactivate prostaglandin I synthase and thereby modulate prostaglandin synthesis.
Products of NOS and COX systems can regulate expression of inducible NOS2 and COX-2 in response to similar and dissimilar stimuli.
Modulation of COX and NOS pathways is principally involved in a variety of pathological conditions, so dissecting their relationship is relevant for therapeutic strategy understanding.