Together, these data elucidate the responses of D1- and D2-type MSNs in NAc to acute cocaine and during the formation of context-reward associations
First-pass extracted concept
D1- and D2-type nucleus accumbens medium spiny neuron activity in cocaine reward
Candidate: concept label1 source documents4 linked claims
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Aliases
D1 and D2 medium spiny neurons in cocaine reward, D1- and D2-type MSNs in NAc
Evidence Snippets
Supporting Sources
Linked Claims
Fiber photometry calcium imaging identified D1 medium spiny neurons in nucleus accumbens as the specific population encoding information about cocaine-associated drug associations.
Quoted textsource-backed
Using fiber photometry calcium imaging we define D1 MSNs as the specific population of cells in NAc that encodes information about drug associations
Direct manipulation of D1 signals using DREADDs prevents contextual associations.
Quoted textsource-backed
Directly manipulating these D1 signals using designer receptors exclusively activated by designer drugs prevents contextual associations.
Chronic cocaine exposure dysregulates D1 signals in a way that prevents extinction and facilitates reinstatement of drug seeking.
Quoted textsource-backed
Chronic cocaine exposure dysregulates these D1 signals to both prevent extinction and facilitate reinstatement of drug seeking to drive relapse.
D1 medium spiny neuron activity increases with a temporal profile that drives drug seeking in response to contextual cues.
Quoted textsource-backed
elucidate the temporal profile with which D1 activity is increased to drive drug seeking in response to contextual cues