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D1 dopamine receptor

Candidate: concept label1 source documents6 linked claims
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Aliases

D1 receptor

Evidence Snippets

Specifically, it will concentrate on the D1 dopamine receptor and intracellular signaling mediated by this receptor subtype.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1behavioral association summarysupports2002Source 1DOIPubMed

Repeated cocaine exposure produces sensitization, and the D1 dopamine receptor and its associated signaling pathway have been implicated in this phenomenon.

Quoted textsource-backed
This article too will review a common behavioral manifestation associated with repeated cocaine exposure, sensitization, and why the D1 dopamine receptor and its associated signaling pathway have been implicated in this phenomenon.
Claim 2mechanistic summarysupports2002Source 1DOIPubMed

The psychostimulant effects of cocaine appear to be mediated by enhanced dopaminergic activity within the mesocorticolimbic circuit.

Quoted textsource-backed
Pharmacologically, the psychostimulant effects of cocaine appear to be mediated by its ability to enhance dopaminergic activity within the mesocorticolimbic circuit.
Claim 3review scope summarysupports2002Source 1DOIPubMed

Cocaine directly prevents reuptake of dopamine, serotonin, and norepinephrine by binding their transport proteins, thereby elevating synaptic concentrations of these neurotransmitters.

Quoted textsource-backed
Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons... Inhibition of re-uptake subsequently elevates the synaptic concentrations of each of these neurotransmitters.
Claim 4review scope summarysupports2002Source 1DOIPubMed

The review centers on cocaine-induced alterations in dopamine-mediated signal transduction, especially intracellular signaling mediated by the D1 dopamine receptor.

Quoted textsource-backed
This review will summarize findings relevant to cocaine-induced alterations in dopamine-mediated signal transduction. Specifically, it will concentrate on the D1 dopamine receptor and intracellular signaling mediated by this receptor subtype.
Claim 5review scope summarysupports2002Source 1DOIPubMed

The review links D1 dopamine receptor-associated signaling to cocaine-induced cellular and behavioral alterations that may affect gene transcription and protein expression.

Quoted textsource-backed
It will describe cocaine-induced cellular and behavioral alterations relevant to this pathway and how these changes potentially effect gene transcription and protein expression.
Claim 6therapeutic hypothesis summarysupports2002Source 1DOIPubMed

Targeting the D1 dopamine receptor and its signaling pathway may provide insight into understanding cocaine addiction.

Quoted textsource-backed
Lastly, this article will discuss how targeting the D1 dopamine receptor and its signaling pathway may offer some insight into understanding cocaine addiction, a somewhat elusive brain disease.