They also suggest that excitation of D2 neurons in NAc supports self-stimulation under some conditions, but fails under others and possibly may even shift to negative avoidance.
First-pass extracted concept
D2 neuron excitation in nucleus accumbens
Candidate: concept label1 source documents3 linked claims
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Aliases
D2 neuronal excitation in NAc, excitation of D2 neurons in NAc
Evidence Snippets
Supporting Sources
Linked Claims
D1 and D2 stimulation in nucleus accumbens recruited heavily overlapping patterns of Fos activation in distant limbic structures.
Quoted textsource-backed
Brain-wide measures indicated that D1 and D2 stimulations in NAc recruited heavily overlapping patterns of Fos activation in distant limbic structures.
Excitation of D2 neurons in nucleus accumbens failed to support positive self-stimulation in the location task and may produce avoidance in some individuals.
Quoted textsource-backed
However, in the location task, D2 mice failed to show positive self-stimulation. If anything, a few D2 individuals gradually avoided the laser location.
Excitation of D2 neurons in nucleus accumbens supports lower but positive self-stimulation in the spout-touch task.
Quoted textsource-backed
By comparison, D2 ChR2 mice showed lower but still positive levels of self-stimulation in the spout-touch task, earning dozens to hundreds of NAc laser illuminations.