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First-pass extracted concept

daily corticosterone release

Candidate: concept label1 source documents3 linked claims
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Aliases

daily corticosterone rhythms, daily rhythms in glucocorticoids

Evidence Snippets

We hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily release of corticosterone.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1genetic perturbation effectsupports2021Source 1DOIPubMed

Loss of Bmal1 in CRH neurons causes arrhythmic PVN CRH calcium activity and reduces the amplitude and precision of daily corticosterone release.

Claim 2integrated mechanism claimsupports2021Source 1DOIPubMed

Daily corticosterone release depends on coordinated clock gene rhythms and neuronal activity rhythms in both SCN VIP neurons and PVN CRH neurons.

Claim 3perturbation effectsupports2021Source 1DOIPubMed

Activation of SCN VIP neurons reduces corticosterone release and PVN CRH calcium activity, whereas inactivation increases them.