evidence stemming from this research clearly demonstrates that cell response to daunorubicin is highly regulated by multiple signaling events
First-pass extracted concept
daunorubicin-induced signaling
Candidate: concept label1 source documents6 linked claims
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Evidence Snippets
Supporting Sources
Linked Claims
Daunorubicin-associated signaling pathways are influenced by lipid products, reactive oxygen species, oncogenes, protein kinases, and external stimuli.
Quoted textsource-backed
These pathways are themselves influenced by a number of lipid products (diacylglycerol, sphingosine-1 phosphate, and glucosyl ceramide), reactive oxygen species, oncogenes (such as the tumor suppressor gene p53), protein kinases (protein kinase C and phosphoinositide-3 kinase), and external stimuli (hematopoietic growth factors and the extracellular matrix).
A sphingomyelinase-initiated sphingomyelin-ceramide pathway is implicated in daunorubicin-induced signaling.
Quoted textsource-backed
including a sphingomyelinase-initiated sphingomyelin-ceramide pathway
MAPK and stress-activated protein kinase/JNK activation are implicated in daunorubicin-induced signaling.
Quoted textsource-backed
mitogen-activated kinase and stress-activated protein/c-Jun N-terminal kinase activation
NF-kappaB is implicated in daunorubicin-induced signaling.
Quoted textsource-backed
transcription factors such as nuclear factor kappa B
The Fas/Fas-ligand system is implicated in daunorubicin-induced signaling.
Quoted textsource-backed
as well as the Fas/Fas-ligand system
Cellular response to daunorubicin is highly regulated by multiple signaling pathways rather than a single pathway.
Quoted textsource-backed
evidence stemming from this research clearly demonstrates that cell response to daunorubicin is highly regulated by multiple signaling events