decidual lymphatic endothelial cells (dLECs) were isolated and cultured from chorioamniotic membranes obtained at cesarean section from women with PE (n = 15) and gestational age-matched controls (n = 15).
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decidual lymphatic endothelial cells
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dLECs
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Isolated decidual lymphatic endothelial cells were identified by LYVE1, Prox1, and CD31 expression.
Decidual lymphatic endothelial cells from severe preeclampsia show gene expression differences relative to controls in lymphatic vessel development, immune cell trafficking, and T-cell activation regulation programs.
Impaired decidual lymphatic vessel function and molecular alterations may disrupt immune regulation and contribute to severe preeclampsia.
Decidual lymphatic endothelial cells from severe preeclampsia have reduced migration, adhesion, morphological differentiation, and lymphatic sprouting compared with controls.
Severe preeclampsia-derived decidual lymphatic endothelial cells exhibit low CCL21 expression and impaired dendritic cell recruitment.
LYVE1-positive lymphatic vessels are present in the decidua.
Severe preeclampsia-derived decidual lymphatic endothelial cells show reduced Akt-eNOS-nitric oxide signaling associated with suppression of decidual cytotoxic T-cell activation in decidua.