DBS is presented as an invasive neuromodulation modality used in Parkinson's disease.
First-pass extracted concept
deep brain stimulation
Candidate: concept label11 source documents18 linked claims
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Aliases
DBS
Extracted Explainers
What the tool is doing
The review presents deep brain stimulation as a functional neurosurgical treatment option for tremor syndromes. It is discussed alongside lesioning approaches and target selection considerations.
Deep brain stimulation is presented as a neuromodulation therapy that alters neural activity across the brain. The abstract includes it as one of the therapies examined through neuroimaging.
The paper treats deep brain stimulation as one of the brain stimulation technique categories used in closed-loop BCI research.
Deep brain stimulation is presented as a surgical treatment modality for Parkinson's disease that replaced lesioning in large part. The abstract specifically attributes this shift to adaptability and reversibility.
Resources required
What problem it solves
The source scaffold places DBS as an established intervention within the Parkinson's disease neuromodulation landscape.
It addresses tremor cases where medication is inadequate or side effects are unacceptable. The review frames it as part of the modern surgical treatment landscape.
It addresses Parkinson's disease motor symptoms within the current surgical treatment landscape.
What it does not solve
The abstract does not claim that DBS is universally optimal for all tremor patients. It emphasizes that treatment choice remains complex and individualized.
The abstract states that current surgical effectiveness remains limited to motor symptoms and does not yet modify the disease process.
Alternatives
Evidence Snippets
While pharmacological therapies and Deep Brain Stimulation (DBS) are standard treatments...
we discuss focused ultrasound state-of-the-art clinically and when relevant in relation to other similar treatment strategies (ie, deep brain stimulation).
Therefore, this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies, including electroencephalography, magnetic resonance imaging, optogenetics, chemogenetics, deep brain stimulation, and brain-computer interfaces.
The document explicitly frames Deep Brain Stimulation (DBS) as established.
Keyword co-occurrence and cluster analysis identified that deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, and focused ultrasound stimulation are the most widely used central nerve stimulation techniques in neuromodulation.
Over decades, the field of functional neurosurgery has evolved from traditional radiofrequency ablation to deep brain stimulation, and more recently, to incisionless high frequency ultrasonic lesional techniques.
therapies such as deep brain and transcranial magnetic stimulation alter neural activity across the brain.
These categories include deep brain stimulation, transcranial magnetic stimulation, transcranial direct-current stimulation, transcranial alternating-current stimulation, and optogenetics.
The indexed abstract and keywords indicate a broad review spanning brain–machine interfaces, deep brain stimulation, microelectrode arrays, prosthetics, transcranial magnetic stimulation, pharmacological and optical approaches, and ethical issues.
Deep brain stimulation, radiofrequency, MR-guided focused ultrasound, gamma knife, levodopa-carbidopa intestinal gel, and apomorphine are now used in the clinical setting for this disease.
The field of surgery initially developed from lesioning procedures and then transitioned largely to deep brain stimulation due to its properties of adaptability and reversibility.
Supporting Sources
Linked Claims
DBS is described as modulating neural firing patterns and promoting neuroplasticity, while FUS is described as enabling transient BBB disruption, enhanced drug delivery, localized neuro-thermal effects, and potential neuroprotection and neurotransmitter regulation.
Quoted textsource-backed
DBS modulates neural firing patterns and promotes neuroplasticity, while FUS allows for precise, transient disruption of the brain barrier (BBB), enhances drug delivery, and induces localized neuro-thermal effects, potentially aiding neuroprotection and neurotransmitter regulation.
The hybrid DBS-FUS modality is described as enhancing therapeutic efficacy through complementary mechanisms, with DBS providing continuous neuromodulation and FUS providing non-invasive precise targeting.
Quoted textsource-backed
This combined modality leverages the continuous neuromodulation of DBS with the non-invasive, precise targeting of FUS, enhancing therapeutic efficacy through complementary mechanisms.
The review investigates neural circuit mechanisms in epilepsy using evidence from electroencephalography, magnetic resonance imaging, optogenetics, chemogenetics, deep brain stimulation, and brain-computer interfaces.
Quoted textsource-backed
Therefore, this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies, including electroencephalography, magnetic resonance imaging, optogenetics, chemogenetics, deep brain stimulation, and brain-computer interfaces.
The evolution of tremor surgery has broadened access and increased therapeutic options, but has made treatment selection more complex and dependent on evidence, personal, medical, social, and economic factors.
Quoted textsource-backed
This evolution has broadened access to surgical treatments for individuals with tremor and has provided both clinicians and patients with a wider range of therapeutic options. Consequently, selecting the most appropriate surgical treatment for an individual has arguably become more complex, relying on a combination of evidence base, personal, medical, social, and economic factors.
Surgical interventions are often required for moderate-severe tremor syndromes or when medication side effects are unacceptable.
Quoted textsource-backed
while medications can be effective in mild cases, surgical interventions are often required in moderate-severe syndromes or when medication side-effects are unacceptable
Radiofrequency ablation, deep brain stimulation, and ultrasonic lesional techniques remain valuable tools that can treat a variety of stereotactic targets using several targeting methods.
Quoted textsource-backed
All these modalities remain valuable tools for the clinicians and can be used to treat a variety of stereotactic targets with several targeting methods.
Neuromodulation technology is receiving increasing research attention and is currently widely used in brain diseases.
Quoted textsource-backed
neuromodulation technology is garnering increasing attention from researchers and is currently widely used in brain diseases
Functional neurosurgery for tremor has evolved from radiofrequency ablation to deep brain stimulation and more recently to incisionless ultrasonic lesional techniques.
Quoted textsource-backed
Over decades, the field of functional neurosurgery has evolved from traditional radiofrequency ablation to deep brain stimulation, and more recently, to incisionless high frequency ultrasonic lesional techniques.
Deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, and focused ultrasound stimulation were identified as the most widely used central nerve stimulation techniques in neuromodulation.
Quoted textsource-backed
Keyword co-occurrence and cluster analysis identified that deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, and focused ultrasound stimulation are the most widely used central nerve stimulation techniques in neuromodulation.
Future neuromodulation research is expected to focus more on deep brain structure stimulation targets and restoration of motor function based on neuroplasticity theory.
Quoted textsource-backed
Future research is expected to delve deeper, particularly into exploring deep brain structure stimulation targets and restoring motor function based on neuroplasticity theory.
Deep brain stimulation is presented as an established invasive neuromodulation intervention for Parkinson's disease.
The review discusses evidence and surgical approaches for essential tremor, Parkinson's disease tremor, and dystonic tremor, including outcomes across treatments and targets, waning benefit, and patient selection for high-intensity focused ultrasound and deep brain stimulation.
Quoted textsource-backed
This educational review discusses the evidence behind, and surgical approaches to, essential tremor, Parkinson's disease tremor and dystonic tremor. Key topics addressed in the educational review include outcomes of different surgical treatments across tremor syndromes and stereotactic targets, waning benefit after surgical treatment, and optimization of patient selection with regards to high-intensity focused ultrasound and deep brain stimulation.
The precise mechanisms of action of neuromodulation therapies are unclear.
Quoted textsource-backed
Neuromodulation relies on changing activity within a specific brain region or circuit, but the precise mechanisms of action of these therapies, is unclear.
Deep brain stimulation and transcranial magnetic stimulation alter neural activity across the brain.
Quoted textsource-backed
therapies such as deep brain and transcranial magnetic stimulation alter neural activity across the brain
Deep brain stimulation, radiofrequency, MR-guided focused ultrasound, gamma knife, levodopa-carbidopa intestinal gel, and apomorphine are used in the clinical setting for Parkinson's disease.
This source is a broad review-like chapter covering multiple brain augmentation modalities including brain-machine interfaces, deep brain stimulation, microelectrode arrays, prosthetics, transcranial magnetic stimulation, pharmacological approaches, optical approaches, and ethical issues.
Parkinson's disease surgery transitioned largely from lesioning procedures to deep brain stimulation because deep brain stimulation is adaptable and reversible.
Quoted textsource-backed
The field of surgery initially developed from lesioning procedures and then transitioned largely to deep brain stimulation due to its properties of adaptability and reversibility.
Current surgical treatment effectiveness in Parkinson's disease remains limited to motor symptoms such as bradykinesia, rigidity, tremor, and medication-induced dyskinesias.
Quoted textsource-backed
its scope of effectiveness remains limited to motor symptoms like bradykinesia, rigidity, tremor and medication-induced dyskinesias