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DELLA proteins

Candidate: concept label1 source documents7 linked claims
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Aliases

DELLAs

Extracted Explainers

What the tool is doing

DELLA proteins are described as negative regulators of GA response. They also interact with other pathway components including GID1 and PIF proteins.

Source 1DOIPubMed

What problem it solves

They provide the review's main mechanistic explanation for how GA responses are repressed until GA perception triggers relief of that repression.

Source 1DOIPubMed

What it does not solve

The abstract does not specify how individual DELLA family members differ or how broadly the mechanism generalizes across all plant lineages.

Source 1DOIPubMed

Alternatives

The abstract contrasts DELLA-centered repression with downstream integration through PIF proteins and ABA-associated regulation via Xerico.

Source 1DOIPubMed

Evidence Snippets

GA signaling is now understood to hinge on DELLA proteins.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1evolutionary summarysupports2008Source 1DOIPubMed

Sequence analysis from Physcomitrella suggests that GID1 and DELLA components evolved early but did not initially interact.

Claim 2mechanistic summarysupports2008Source 1DOIPubMed

Binding of DELLA proteins to PIF3, PIF4, and PIF5 integrates light and GA signaling by preventing these PIFs from acting as positive transcriptional regulators of growth in the dark.

Claim 3mechanistic summarysupports2008Source 1DOIPubMed

DELLA proteins negatively regulate GA response in part by activating genes including Xerico, which upregulates an abscisic acid pathway antagonistic to GA.

Claim 4mechanistic summarysupports2008Source 1DOIPubMed

DELLA proteins promote transcription of the GA receptor GID1 and indirectly regulate GA biosynthesis genes, contributing to GA responsiveness and feedback control.

Claim 5mechanistic summarysupports2008Source 1DOIPubMed

GA binds within a pocket of GID1, changes GID1 conformation, and increases the affinity of GID1 for DELLA proteins.

Claim 6mechanistic summarysupports2008Source 1DOIPubMed

GA signaling is centered on DELLA proteins, which act as negative regulators of GA response.

Claim 7mechanistic summarysupports2008Source 1DOIPubMed

The GA-GID1-DELLA complex has increased affinity for an F-box protein, after which DELLAs are degraded via the proteasome and GA induces growth through DELLA degradation.