First-pass extracted concept

descending modulation

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Decades of research have suggested that stimulation of supraspinal structures, such as the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM), inhibits nocifensive responses to noxious stimulation through a process known as descending modulation.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2023MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1biological scopesupports2023Source 1DOI PubMed

Recent work revealed that PAG and RVM neuronal cell types are important in descending modulation of pruriceptive as well as nociceptive behaviors.

Claim 2mechanism summarysupports2023Source 1DOI PubMed

Stimulation of supraspinal structures such as the PAG and RVM inhibits nocifensive responses to noxious stimulation through descending modulation.

Claim 3review scopesupports2023Source 1DOI PubMed

New technical advances enabling cell type-specific manipulation and recording of neuronal activity have supported and expanded long-standing views on descending modulation.