First-pass extracted concept

designer receptors exclusively activated by designer drugs

Candidate: concept label4 source documents9 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

DREADD, DREADDs

Evidence Snippets

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer a powerful means for reversible control of neuronal activity through systemic administration of inert actuators.

Evidence 1Source 1DOI PubMedprovenance

Here, we use excitatory and inhibitory designer receptors exclusively activated by designer drugs (DREADD) to study the effects of acute chemogenetic manipulations...

Evidence 2Source 2DOI PubMedprovenance

Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors.

Evidence 3Source 3DOI PubMedprovenance

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are engineered receptors that allow for genetically targeted, reversible manipulation of cellular activity via systemic drug administration.

Evidence 4Source 4DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2primary paper2024MEDDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Source 3primary paper2023MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Source 4primary paper2023MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1capabilitysupports2025Source 1DOI PubMed

DREADDs enable reversible control of neuronal activity through systemic administration of inert actuators.

Quoted textsource-backed

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer a powerful means for reversible control of neuronal activity through systemic administration of inert actuators.

Claim 2construct design effectsupports2025Source 1DOI PubMed

Co-expressed protein tags reduced overall DREADD expression levels.

Quoted textsource-backed

The presence of protein tags significantly influenced expression levels, with co-expressed protein tags reducing overall expression levels.

Claim 3biological effectsupports2024Source 2DOI PubMed

Acute chemogenetic neuronal activation increases microglia and astrocyte reactivity.

Quoted textsource-backed

and increases microglia and astrocyte reactivity

Claim 4biological effectsupports2024Source 2DOI PubMed

Acute chemogenetic neuronal activation reduces synaptic density.

Quoted textsource-backed

We show that acute chemogenetic neuronal activation reduces synaptic density

Claim 5biological effectsupports2024Source 2DOI PubMed

Acute chemogenetic neuronal silencing increases synaptic density and decreases glial reactivity.

Quoted textsource-backed

Conversely, acute silencing increases synaptic density and decreases glial reactivity.

Claim 6mechanistic inferencesupports2024Source 2DOI PubMed

The study provides evidence for fast, activity-dependent, bidirectional interactions between neurons and glial cells.

Quoted textsource-backed

Together, our work provides evidence of fast, activity-dependent, bidirectional interactions between neurons and glial cells.

Claim 7specificity or selectivitysupports2024Source 2DOI PubMed

Acute chemogenetic neuronal activation does not affect parvalbumin-positive neurons but affects perineuronal nets.

Quoted textsource-backed

but does not affect parvalbumin (PV+) neurons, only perineuronal nets (PNN)

Claim 8experimental recommendationsupports2023Source 3DOI PubMed

Chemogenetic experiments should include a DREADD-free control group injected with the same actuator.

Quoted textsource-backed

Therefore, any chemogenetic experiment should include a DREADD-free control group injected with the same CNO, C21, or newly developed actuator.

Claim 9tool functionsupports2023Source 4DOI PubMed

DREADDs are engineered receptors that enable genetically targeted, reversible manipulation of cellular activity through systemic drug administration.

Quoted textsource-backed

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are engineered receptors that allow for genetically targeted, reversible manipulation of cellular activity via systemic drug administration.