First-pass extracted concept

deubiquitinases

Candidate: concept label1 source documents3 linked claims

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Aliases

deubiquitinating enzymes, DUBs

Extracted Explainers

DUBs remove or reverse ubiquitin signals from proteins. The review frames them as sophisticated regulators of the ubiquitin code.

They counteract ubiquitination-based signaling and thereby help control diverse cellular processes.

The abstract does not specify any single DUB as a discrete tool or provide operational details for using one experimentally.

The abstract contrasts DUB action with ubiquitination itself, including mono- and polyubiquitination and mixed polymers with SUMO or NEDD8.

Evidence Snippets

Deubiquitinases (DUBs) reverse ubiquitin signals with equally high sophistication.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2017Annual Review of BiochemistryDOI PubMed

Linked Claims

Claim 1functional rolesupports2017Source 1DOI PubMed

Deubiquitinases reverse ubiquitin signals with high sophistication.

Claim 2regulation summarysupports2017Source 1DOI PubMed

Deubiquitinase regulation includes mechanisms that modulate catalytic activity.

Claim 3specificity frameworksupports2017Source 1DOI PubMed

Deubiquitinases encompass many layers of specificity that control the ubiquitin code.