The review presents developmental bioelectricity as a regulator of patterning and remodeling in multicellular tissues. It is framed as a substrate for information processing in non-neural cells.
First-pass extracted concept
developmental bioelectricity
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The mechanisms of developmental bioelectricity - the ability of all cells to form electrical networks that process information - suggest a plausible set of gradual evolutionary steps...
Here, we review recent data on developmental bioelectricity as a regulator of patterning
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Linked Claims
The proposed framework is stated to have implications for cancer, biomedicine, artificial intelligence, and exobiology.
Quoted textsource-backed
This set of hypotheses provides a novel perspective on numerous phenomena, such as cancer, and makes several unique, testable predictions ... with implications not only for evolutionary developmental biology but also for biomedicine and perhaps artificial intelligence and exobiology.
Developmental bioelectricity is proposed as a mechanistic substrate by which multicellularity and higher cognitive capacities can emerge from single-cell homeostasis.
Quoted textsource-backed
The mechanisms of developmental bioelectricity ... suggest a plausible set of gradual evolutionary steps that naturally lead from physiological homeostasis in single cells to memory, prediction, and ultimately complex cognitive agents
Target morphology could be encoded within tissues as a kind of memory using molecular mechanisms and algorithms analogous to those exploited by the brain.
A fundamental challenge in regenerative medicine is translating progress in molecular genetics into control of large-scale organismal anatomy.