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First-pass extracted concept

developmental neurotoxicity

Candidate: concept label1 source documents3 linked claims
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Extracted Explainers

What the tool is doing

This concept captures harmful effects on the developing nervous system caused by exposure to environmental agents during development. The review presents it as arising from interference with core developmental processes.

Source 1DOIPubMed

What problem it solves

It provides a common label for relating diverse toxicants and insults to shared neurodevelopmental consequences.

Source 1DOIPubMed

What it does not solve

It does not by itself identify which developmental stage, mechanism, or behavioral domain is most affected in a given case.

Source 1DOIPubMed

Alternatives

The abstract discusses specific developmental processes and behavioral domains as complementary ways to organize the evidence.

Source 1DOIPubMed

Evidence Snippets

Developmental exposure of animals or humans to numerous agents (e.g., X-ray irradiation, methylazoxymethanol, ethanol, lead, methyl mercury, or chlorpyrifos) demonstrates that interference with one or more of these developmental processes can lead to developmental neurotoxicity.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1review summarysupports2000Source 1DOIPubMed

Developmental exposure to neurotoxicants may accelerate age-related decline in function.

Quoted textsource-backed
Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function.
Claim 2review summarysupports2000Source 1DOIPubMed

Interference with developmental processes such as proliferation, migration, differentiation, synaptogenesis, myelination, or apoptosis can lead to developmental neurotoxicity.

Quoted textsource-backed
Developmental exposure of animals or humans to numerous agents ... demonstrates that interference with one or more of these developmental processes can lead to developmental neurotoxicity.
Claim 3review summarysupports2000Source 1DOIPubMed

Some human clinical disorders may result from interference with normal ontogeny of developmental processes in the nervous system.

Quoted textsource-backed
various clinical disorders in humans (e.g., schizophrenia, dyslexia, epilepsy, and autism) may also be the result of interference with normal ontogeny of developmental processes in the nervous system