First-pass extracted concept

diacylglycerol

Candidate: concept label2 source documents2 linked claims

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Aliases

DAG

Evidence Snippets

Rather, strong evidence supports a role for diacylglycerol in the blunting of insulin signaling.

Evidence 1Source 1DOIprovenance

The review title explicitly names diacylglycerol as a second messenger.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2008Journal of Lipid ResearchDOI

1 evidence snippet 1 linked claim Claim 1

Source 2review1984Biochemical JournalDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1mechanistic summarysupports2008Source 1DOI

The review argues that triglyceride itself is unlikely to be the main mediator of fatty-acid-induced insulin resistance, whereas diacylglycerol is strongly implicated in blunting insulin signaling.

Quoted textsource-backed

However, it is important to point out that current evidence argues against triglyceride itself being the culprit in these fatty-acid-mediated actions. Rather, strong evidence supports a role for diacylglycerol in the blunting of insulin signaling.

Claim 2review scope statementsupports1984Source 2DOI PubMed

The source reviews inositol trisphosphate and diacylglycerol as second messengers.