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disuse osteoporosis

Candidate: concept label1 source documents6 linked claims
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Evidence Snippets

Disuse osteoporosis describes a state of bone loss due to local skeletal unloading or systemic immobilization.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1mechanistic associationsupports2021Source 1DOIPubMed

The low bone formation state in disuse osteoporosis has been linked to high levels of sclerostin.

Quoted textsource-backed
The fact that the low bone formation state has been linked to high levels of the osteocyte-secreted protein sclerostin
Claim 2mechanistic rolesupports2021Source 1DOIPubMed

Osteocytes are important in the pathogenesis of disuse osteoporosis.

Quoted textsource-backed
Previous basic research has primarily involved rodent models based on tail suspension, spaceflight and other immobilization methods, which have underlined the importance of osteocytes in the pathogenesis of disuse osteoporosis.
Claim 3mechanistic rolesupports2021Source 1DOIPubMed

Osteocytes sense mechanical loading through mechanosensors that convert extracellular mechanical signals into intracellular biochemical signals and gene-regulatory responses.

Quoted textsource-backed
osteocytes sense mechanical loading through mechanosensors that translate extracellular mechanical signals to intracellular biochemical signals and regulate gene expression
Claim 4review summarysupports2021Source 1DOIPubMed

Alterations in osteocytic pathways appear crucial to bone loss associated with unloading.

Quoted textsource-backed
Overall, disuse represents one of the major factors contributing to immediate bone loss and osteoporosis, and alterations in osteocytic pathways appear crucial to the bone loss associated with unloading.
Claim 5review summarysupports2021Source 1DOIPubMed

Disuse osteoporosis is associated with relatively increased bone resorption and decreased bone formation.

Quoted textsource-backed
immobilization leads to immediate bone loss in both the trabecular and cortical compartments accompanied by relatively increased bone resorption and decreased bone formation
Claim 6review summarysupports2021Source 1DOIPubMed

Immobilization leads to immediate bone loss in both trabecular and cortical bone compartments.

Quoted textsource-backed
Clinical studies have outlined that immobilization leads to immediate bone loss in both the trabecular and cortical compartments