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DMT1-transferrin system

Candidate: concept label1 source documents3 linked claims
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Aliases

divalent metal transporter 1 (DMT1)-transferrin

Extracted Explainers

What the tool is doing

The review describes the DMT1-transferrin system as an iron regulatory mechanism that increases intracellular iron levels during iron deficiency. The abstract links this increase to endosomal trafficking.

Source 1DOIPubMed

What problem it solves

It addresses how cells raise intracellular iron when iron is deficient.

Source 1DOIPubMed

What it does not solve

The abstract does not describe any engineered use, delivery format, or assay implementation for this system.

Source 1DOIPubMed

Alternatives

The abstract places it alongside the hepcidin-ferroportin axis and the ferritin-NCOA4 system as alternative iron-regulatory routes.

Source 1DOIPubMed

Evidence Snippets

including hepcidin-ferroportin, divalent metal transporter 1 (DMT1)-transferrin, and ferritin-nuclear receptor coactivator 4 (NCOA4). During iron deficiency, DMT1-transferrin ... increase intracellular iron levels via endosomes
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1high level conclusionsupports2023Source 1DOIPubMed

The review concludes that intracellular iron homeostasis is vital for maintaining inflammatory homeostasis.

Claim 2mechanistic summarysupports2023Source 1DOIPubMed

During iron deficiency, DMT1-transferrin and ferritin-NCOA4 systems increase intracellular iron levels via endosomes and ferritinophagy, respectively.

Claim 3mechanistic summarysupports2023Source 1DOIPubMed

The review identifies hepcidin-ferroportin, DMT1-transferrin, and ferritin-NCOA4 as intracellular iron regulatory mechanisms.