First-pass extracted concept

DNA double-strand breaks

Candidate: concept label1 source documents3 linked claims

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Aliases

DSBs

Extracted Explainers

What the tool is doing

DNA double-strand breaks are the damage readout used to connect wakefulness, sleep, and chromosome dynamics in neurons.

Source 1DOI PubMed

What problem it solves

This damage measure lets the paper frame sleep as reducing accumulated neuronal DNA damage.

Source 1DOI PubMed

What it does not solve

The abstract does not identify the exact measurement method or establish a conserved molecular sleep marker.

Source 1DOI PubMed

Evidence Snippets

Manipulation of sleep, chromosome dynamics, neuronal activity, and DNA double-strand breaks (DSBs) showed that chromosome dynamics are low and the number of DSBs accumulates during wakefulness.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019Nature CommunicationsDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1causal mechanismsupports2019Source 1DOI PubMed

Sleep increases chromosome dynamics, and these dynamics are necessary to reduce DNA double-strand breaks.

Quoted textsource-backed

In turn, sleep increases chromosome dynamics, which are necessary to reduce the amount of DSBs.

Claim 2functional hypothesissupports2019Source 1DOI PubMed

The restorative function of sleep is proposed to be nuclear maintenance.

Quoted textsource-backed

and propose that the restorative function of sleep is nuclear maintenance.

Claim 3state associationsupports2019Source 1DOI PubMed

During wakefulness, chromosome dynamics are low and DNA double-strand breaks accumulate.

Quoted textsource-backed

Manipulation of sleep, chromosome dynamics, neuronal activity, and DNA double-strand breaks (DSBs) showed that chromosome dynamics are low and the number of DSBs accumulates during wakefulness.