First-pass extracted concept

DNA methylation

Candidate: concept label1 source documents5 linked claims

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Evidence Snippets

This review concerns DNA methylation, focusing on the generation, inheritance, and biological significance of genomic methylation patterns in the development of mammals.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2002Genes & DevelopmentDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1comparative epigenetic modelsupports2002Source 1DOI PubMed

DNA methylation and Pc-G/trx complexes may represent alternative epigenetic memory systems that have been interchanged over evolutionary time.

Claim 2functional rolesupports2002Source 1DOI PubMed

Heritable methylation states support the idea that DNA methylation is adapted for a cellular memory function during development.

Claim 3mechanistic modelsupports2002Source 1DOI PubMed

DNA methylation may primarily affect genes that are already silenced by other mechanisms in the embryo.

Claim 4mechanistic modelsupports2002Source 1DOI PubMed

Embryonic transcription may exclude the DNA methylation machinery.

Claim 5review scope statementsupports2002Source 1DOI PubMed

DNA methylation is presented as a heritable epigenetic system involved in mammalian development.